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Understanding Endocannabinoid

Endocannabinoid System
• Master control system
• Group of endogenous cannabinoid receptors located in the mammalian brain
and throughout the central & peripheral nervous systems
• Involved in the direct regulation of appetite, metabolic health,
pain/inflammation, thermoregulation, intraocular pressure, sensation, muscle
control, motivation/reward, mood and memory
• Involved in learning and synaptic plasticity
• Endocannabinoids are messengers that communicate via cannabinoid receptors
• Anandamide and 2AG
• Main Receptors: CB1 and CB2
• Also, non-CB receptors

• Endocannabinoid System tone requires CB1 and CB2 balance
• Optimal CB1 activity decreases anxiety, reduces pain, decreases
inflammation, controls sensory perception (how we respond to
stress), memory and cognitive function
• Poor diet filled with processed foods, stress etc. overstimulates CB1
• Overstimulation of CB1 has many negative side effects and could lead
to anxiety, inflammation, insulin resistance, sleep, etc. in the body

How does CBD help balance CB1 and CB2?
CBD is able to balance the constant overstimulation of the CB1
receptor. It does this in three ways:
1. CBD acts as an antagonist to the CB1 receptor
2. It can gently stimulate CB2
3. CBD is able to stimulate receptors outside of endocannabinoid
system which help to modulate pain, inflammation and decrease